Django and Flask are two of the most popular Python frameworks for web development, each with its strengths and weaknesses. Django is a full-fledged framework offering a robust set of built-in features such as an ORM, authentication system, and admin panel, making it ideal for larger projects that require a lot of functionality out of the box. On the other hand, Flask is a micro-framework that gives developers more control and flexibility, allowing them to choose which components they want to use. Flask is typically favored for smaller, lightweight applications where performance and minimalism are prioritized. Choosing between Django and Flask in 2024 depends on the size, complexity, and scalability needs of your project.